Effects of some ambient molecules on the surface conductivity of zinc oxide at room temperature were studied. The dark conductivity was found to increase by adsorbing electron donating molecules such as NH3 and CH3NH2, decreased considerably by adsorbing electron acceptors (O2NO, NO2 etc.) and unchanged in neutral molecules (N2 and CO2). The photoconductive sensitivity was of considerable amount only when the measurement was done in the electroaffeinitive gases. It was suggested that there exists a parallel relation between the chemical activity of the ambient molecules and the rate of current decay process after cease of the irradiation.