Abstract
A murine mammary adenocarcinome was treated with intraperitoneal photofrin II and Lascr (10 mW, 632 nm. He-Ne laser), Photofrin II was given intraperitoneally 4 h before 30-min laser treatment. A total of six photofrin II/laser treatments. given at 3-4 day intervals. rwsultwd in 52.6% complete response, the cure rate was 26.3%; BCG or PD60 were given in association with PDT to CBA mice with mammary carcinoma. Addition of nonspecific immunostimulants significantly increased the antitumour effects of PDT, and the combination of PDT + PD60 resulted in the highest incidence of complete tumour regression (8.1%).
Enhanced activity of phytohemagglutinin-M response T-lymphocytes and natural killer cells capable of killing K562 tumour cells was noted.
These experimental observations i.e. marked inhibition of the mammary adenocarcinoma developed due the 'combined' PDT-immunothcrapy, suggest the possible use of this new methodology as an adjuvant in clinical practice.
