CMOS image sensor for optical measurement of cranial nerve activity

Abstract

Intrinsic Optical Signal (IOS) indicates activities of brain neurons, and is one of the optical imaging methods, which records in vivo activities of cerebral cortical neurons. We designed two types of CMOS image sensor devices using 0.35-μm standard CMOS process for IOS imaging. In this paper, we describe the design details, device packaging and characterization of the sensors.