Utilization of antihistamine drug for production of local anesthesia in the dental clinic.

Abstract

Unusual reactions following the administration of a local anesthetic agent are frequently claimed by new patients.

Unfortunately, available clinical and laboratory tests are not always conclusive in either proving or disproving such claims. In such cases the patients are usually admitted to the hospital and dental treatment are accomplished under general anesthesia.

Since antihistamine is known to possess local anesthetic properties, Promethazine hydrochloride was used in two cases as a local anesthetic agent.

From the fact that a larger quantity of promethazine hydrochloride-epinephrine was required for satisfactory local anesthesia than Lidocaine-epinephrine, we suggest that it should be used under intravenous sedation or N₂O-O₂ inhalation.