Association of insulin resistance indexes QUICKI and HOMA-IR with the parameters of metabolic syndrome in non-diabetes Japanese male population

Abstract

The metabolic syndrome is a common and complex disorder combining obesity, dyslipidemia, hypertension, and insulin resistance (IR). In the present study, we conducted the observational study in 126 non-diabetes Japanese male population, who visited our clinic for their routine medical check-up, about the relationship between IR indexes and parameters of metabolic syndrome. IR was assessed by both quantitative insulin check index (QUICKI) and homeostasis model assessment for IR (HOMA-IR). Body mass index, body fat content and blood pressure were related with QUICKI and HOMA-IR, but better association was observed with QUICKI. There was no significant association between age and IR indexes. In addition to the fasting plasma glucose (PG) and immunoreactive insulin (IRI) levels, the concentrations of PG and IRI at 30, 60 and 120 min during 75g oral glucose tolerance test were associated with HOMA-IR and QUICKI. Serum triglyceride concentration was associated with QUICKI and HOMA-IR, and serum HDL-cholesterol was related to QUICKI. On the contrary, none of serum total cholesterol, LDL-cholesterol or non-HDL cholesterol concentration was associated with IR indexes. These results suggest that IR was significantly related with the progress of metabolic syndrome even in non-diabetes Japanese male population. Early evaluation of IR by QUICKI would be expected to contribute to the prevention of cardiovascular event due to metabolic syndrome.