Abstract
The treatment of metastatic seedings of lung cancer has not been fully investigated. To more fully research this treatment method, a chemosensitivity test of anticancer drugs diluted with distilled water using resected lung cancer tissues was performed. The resulting solution was given to a group of patients. Lung cancer tissue from 30 patients was divided into 3 mm square cubes and exposed for an hour to CDDP, VP-16 or CBDCA diluted with distilled water. The anticancer drug sensitivity was evaluatd using MTT colorimetric assay. The results showed that all three drugs proved to be more effective after dilution with distilled water. Of the three solutions, CBDCA 2 mg/ml was the most effective. Based on this reslt, we twice intrapleurall administered CBDCA 450 mg diluted with 100 ml of distilled water to four patients with metastatic seedings of lung cancer. The pleuritis carcinomatosa was well controlled with three patients, with light side effects. From our results, we concluded that a treatment of CBDCA diluted with distilled water might be more effective than a panpleuropneumonectomy in treating patients with metastaic seedings of lung cancer.
