電子タバコ用リキッドに含有されるΔ⁹-およびΔ⁸-テトラヒドロカンナビノールアセテートの保存時における安定性（第1報）

抄録

 The stability of Δ⁹‒tetrahydrocannabinol acetate (Δ⁹‒THC‒OAc) and Δ⁸‒tetrahydrocannabinol acetate (Δ⁸‒THC‒OAc) in e-liquid during storage was investigated. Δ⁹‒THC‒OAc liquids in cartridges were stored at 80℃ or 30℃ for 28 days. The relative concentrations of cannabinoids in the liquids were measured by gas chromatography with flame ionization detection. Δ⁹‒THC‒OAc decreased during storage at either temperature. Δ⁹‒THC, a minor impurity, also decreased. Δ⁸‒THC‒OAc liquid in a cartridge was stored at 80℃ for 57 days. The concentration of Δ⁸‒THC‒OAc and Δ⁸‒THC, a minor impurity, did not change during that time. Cannabinol acetate increased in all liquids, and unknown products were also detected by gas chromatography/mass spectrometry (GC/MS). The Δ⁹‒THC‒OAc and Δ⁸‒THC‒OAc liquids were subjected to GC/MS to detect representative diluents, glycerol, propylene glycol, and polyethylene glycol 400, but none of these were detected.