2020 Volume 69 Issue 1 Pages 17-24
Disseminated intravascular coagulation (DIC) is an acquired syndrome characterized by the systemic activation of blood coagulation occurring in the presence of various serious diseases, resulting in microvascular thrombosis in various organs. The main objective of this study was to clarify the role of oxidative stress and tissue factor (TF) in the pathogenesis of DIC in patients with acute leukemia. We measured both oxidation and anti-oxidation activities simultaneously in sera from 40 patients with acute myelogenous leukemia (AML), 20 patients with chronic myelogenous leukemia (CML), and 665 healthy volunteers. To obtain a parameter representing an overall shift toward oxidative stress, the oxidative stress index (OSI) was calculated using the following formula: OSI = (d-ROMs/BAP) × 8.85. We found that the OSIs were clearly higher in sera of AML patients than in those of CML patients and healthy volunteers, and the OSIs were significantly higher in AML patients with DIC than in those without DIC. In addition, the present study confirmed that the prevalence of DIC was significantly higher in AML patients with high TF concentrations (8/11 patients, 72.7%) than in those with normal TF concentrations (3/29 patients, 10.3%). These results suggest that the evaluations of OSI and TF are useful for predicting the development and progression of DIC in AML patients.
