2022 Volume 71 Issue 4 Pages 657-666
Recently, the throughput, performance, and usability of automated hematology analyzers have been improved. This time, we had an opportunity to evaluate XR-1000 of the XR-Series Automated Hematology Analyzer newly developed by Sysmex. We evaluated its performance in the detection of immature granulocytes (IGs) and immature platelet fractions (IPFs) as new reportable parameters and the detectability of abnormal cells, in addition to its basic performance evaluation. It showed good performance in terms of repeatability for CBC and good correlation with Sysmex XN-9000, our current analyzer. For DIFF parameters, correlation with microscopy count was also good. Correlation of the IG% with the microscopy count and the Sysmex DI-60 automated digital imaging analyzer and the concordance rate with the microscopy count were also good. Regarding IPF, repeatability and correlation with the XN-9000 were good. In a hemolytic uremic syndrome case, there was an IPF increase that preceded the PLT increase, and the usefulness of IPF as a platelet hemopoiesis marker was indicated. The concordance rate between abnormal flags and microscopy results for blasts, abnormal lymphocytes, and atypical lymphocytes was good. Finally, the visibility of the appearance position of the cell population was improved by the three-dimensional scattergram, which is a new feature displayable in the XR-Series. In conclusion, the XR-Series can rapidly provide clinically useful information and improve operational efficiency.
