Common background features of fibrin casts positive patients without persistent proteinuria of 2+ or higher

Abstract

Fibrin casts, which are highly suggestive of local renal hypercoagulability associated with high proteinuria, can also be observed in the absence of high proteinuria. In this study, the shared background characteristics of six patients without persistent proteinuria of 2+ or higher were investigated. All six patients showed a tendency of thrombogenesis and exhibited one of three patterns: glomerular hemorrhage, disease, and adverse drug reactions. The results suggested that the detection of fibrin casts in urine sediments of patients having a tendency of thrombogenesis might aid in the prediction of diseases and other conditions. Furthermore, the appearance of fibrin casts in urine might be associated with the leakage of protein components that predispose the urine to thrombosis.