2025 Volume 74 Issue 2 Pages 422-427
Platelet products also contain small amounts of red blood cells, but considerations such as the selection of antigen-negative blood for irregular antibody-positive patients are not currently made. In the present case, we experienced a case detected anti-E by secondary immune response. A man in his 70s was started on AZA therapy for MDS in March 20XX − 2. In January 20XX, an irregular antibody test was positive and the identification test was identified anti-E. All of Recent erythrocyte products contained DCCee, but the donor antigen of the platelet product was DCcEe. Irregular antibody tests were only positive for the ficin method. DTT treatment revealed anti-E of IgG type. Differential tests for mimicking antibodies were performed and mimicking antibodies were excluded. After the detection of anti-E, E-antigen-positive platelet products were transfused, but no haemolytic findings were observed. The results suggest that multiple rounds of immunosensitisation may be required to reactivate antibodies by platelet products. On the basis of this case, we will seek to investigate the possibility that platelet transfusion induces a secondary immune response and the production of irregular antibodies.
