The results of laboratory measurements are presented in this paper. The relationship of the energy-loss factor with the density of gas-liquid mixtures was investigated. The energy-loss factor decreases with decreasing the density of mixtures and approaches a minimum which is nearly equal to 0.006. Considering on the results of the present study and the published articles, the values of energy-loss factor obtained from the chart proposed by Poettmann and Carpenter seem to be upper limit. The flow was observed visually in this experiment and it was found that the transition from plug flow to mist flow occured when the density of mixtures decresed to a constant value which depended on the rate of liquid flow.