2005 年 20 巻 2 号 p. 160-164
Hypersensitivity pneumonitis is a common type IV, or delayed allergic reaction caused by inhalation of aerosol fungi, solvents or chemical substances; multiple epithelioid cell granulomas are formed in the lungs of patients with this disease. In its early stage most of the cases are reversible if the etiologic agent is identified and removed from environment. However, it can progress to irreversible fibrosis if exposure continuous. In this study, the concept of type IV allergy reaction and the features of and further responses to such allergies including hypersentivity pneumonitis are described.