微小粒子・エアロゾルに含まれるPAHs による生体影響

―免疫細 胞への影響に注目して―

抄録

This paper reviews the effects of chemicals such as polycyclic aromatic hydrocarbons (PAHs) and their derivatives, which are major chemical components in particulate matter (PM), on immune cells. First, we introduce some biomarkers for the health effects of PM. We also show that cytotoxicity and/or inflammatory responses were induced by some PAH derivatives containing hydroxyl, carbonyl, nitro, or amino groups, indicating that the toxicological and inflammatory effects of chemicals may be related to their structures, such as functional group and isomer.