Biological Evaluation of Polymerized PEMA-TSA / HX (Polyethyl Methacrylate Methacryloyloxyethyl Methyl Succinate / dimethacrylate 1,6 Hexanediol)

Masashi OKANO; Tatsuhide HAYASHI; Takafumi ASAI; Souichiro HAMAJIMA; Masaki ASAKURA; Yamato SATO; Takashi KIRIYAMA; Tatsushi KAWAI

doi:10.11223/jarde.10.151

ORIGINAL ARTICLES

Biological Evaluation of Polymerized PEMA-TSA / HX (Polyethyl Methacrylate Methacryloyloxyethyl Methyl Succinate / dimethacrylate 1,6 Hexanediol)

Masashi OKANO, Tatsuhide HAYASHI, Takafumi ASAI, Souichiro HAMAJIMA, Masaki ASAKURA, Yamato SATO, Takashi KIRIYAMA, Tatsushi KAWAI

Author information

Masashi OKANO
Department of Dental Materials Science, School of Dentistry, Aichi-Gakuin University, Nagoya, Japan
Tatsuhide HAYASHI
Department of Dental Materials Science, School of Dentistry, Aichi-Gakuin University, Nagoya, Japan
Takafumi ASAI
Department of Dental Materials Science, School of Dentistry, Aichi-Gakuin University, Nagoya, Japan
Souichiro HAMAJIMA
Department of Dental Materials Science, School of Dentistry, Aichi-Gakuin University, Nagoya, Japan
Masaki ASAKURA
Department of Dental Materials Science, School of Dentistry, Aichi-Gakuin University, Nagoya, Japan
Yamato SATO
Department of Dental Materials Science, School of Dentistry, Aichi-Gakuin University, Nagoya, Japan
Takashi KIRIYAMA
Department of Dental Materials Science, School of Dentistry, Aichi-Gakuin University, Nagoya, Japan
Tatsushi KAWAI
Department of Dental Materials Science, School of Dentistry, Aichi-Gakuin University, Nagoya, Japan

Keywords: Resin, L929, MC3T3-E1, Cell proliferation test, Subcutaneous implantation test

JOURNAL FREE ACCESS

2013 Volume 10 Issue 3 Pages 151-162

DOI https://doi.org/10.11223/jarde.10.151

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Abstract

Polyethyl methacrylate methacryloyloxyethyl methyl succinate/dimethacrylate 1,6 hexanediol (PEMA-TSA/HX) resin has been developed to solve biological problems caused by methacrylate resins, which are commonly used in dentistry and medicine. We previously reported its physical and mechanical properties in detail. The purpose of this study was to examine the biocompatibility of PEMA-TSA/HX resin.Biocompatibility of the resin towards fibroblast-like and osteoblast-like cells was evaluated according to the methods in ISO 10993-5 and a subcutaneous implantation test (ISO 10993-6) was carried out. The PEMA-TSA/HX resin showed favorable biological affinity, both in vitro and in vivo, compared with Osteobond^®, which is a current implantable resin material commonly used in orthopedic surgery. It is therefore considered to have many potential clinical applications.

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