Utility of Prototype Porous Titanium as a Bone Regeneration Scaffold

Abstract

This study examined titanium onto which bioactive factors were adsorbed, with the objective of developing a scaffold with many pores that could be expected to promote cell infiltration. Titanium powder was mixed with ammonium hydrogen carbonate as a binder in a 5:5 ratio by weight, and a method based on the powder metallurgy method was used to construct a prototype scaffold. Bone morphogenetic protein (BMP) was adsorbed onto the prototype scaffold, and its osteoinductive potential was evaluated. The results showed that the prototype scaffold possessed pores capable of infiltration by cells, and that sufficient osteoinduction was possible without suppressing the activity of BMP.