Three-Dimensional Analysis and Longitudinal Observation for Osteoinductivity Induced by Bone Morphogenetic Protein

抄録

To obtain the basic information concerning time-sequential development of new bone in the same mouse, micro X-ray CT system was adopted. A cone beam type CT system, for small animals, enabled to extract three-dimensional (3D) images from the time point of bone morphogenetic protein (BMP) implantation through 3–4 weeks postoperatively when usually new ossification could be observed histologically. The results obtained showed the process of new bone formation by BMP from 3D viewpoint. BMP initial contact area to tissue reflected the final shape of new bone, and this observation suggested the technical method to prepare the composite of BMP and scaffold.