Journal of Oral Tissue Engineering
Online ISSN : 1880-0823
Print ISSN : 1348-9623
ISSN-L : 1348-9623
ORIGINAL ARTICLES
Study of the Mutagenicity of Prototype Ag-In, Porcelain Bonding and Au-Ag-Pd Alloys Containing Indium using the Umu-test
Koichi IMAITetsunari NISHIKAWATomoharu OKAMURAAkio TANAKATatsuro MIYAKEIsao TAMURAHiroki ISHIKAWATomio ISEKIShosuke MORITAHirofumi SAWAITadashi OHKUBOMuneyasu SHIDAKazuhiko SUESE
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2015 年 13 巻 1 号 p. 27-33

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The carcinogenicity of indium and its compounds is of concern, and so the Ministry of Health, Labour and Welfare specified these as chemicals which may be carcinogenic to humans by ministerial ordinance. Many carcinogens act on DNA and cause mutation, leading to cancerization. Accordingly, mutagenicity is closely involved in carcinogenicity. We extracted each component from alloy powders of prototype indium-containing silver alloy, alloy for porcelain bonding, and gold-silver-palladium alloy, and investigated their mutagenicity using the umu-test, which is a mutagenicity screening method. This test method utilizes expression of the SOS genes which repair injured DNA in bacteria, and the mutagenicity of many chemicals can be detected, similarly to the Ames test. A positive reaction was detected in the prototype Ag-indium alloy, but the alloy for porcelain bonding and gold-silver-palladium alloy were negative. It was clarified that close investigation of metal indium and commercial indium alloys is necessary.

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© 2015 by Japanese Association of Regenerative Dentistry
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