Journal of Oral Tissue Engineering
Online ISSN : 1880-0823
Print ISSN : 1348-9623
ISSN-L : 1348-9623
ORIGINAL ARTICLES
Effects of Transforming Growth Factor-β1 and Bone Morphogenetic Protein-2 on Bone Formation using a Bioabsorbable Scaffold at Palatal Sites in Rats
Kozo YAMAJIAkihito YOKOYAMAYasushi SHIMADATsutomu SUGAYANaoko OHARAKumiko MATSUZAKIEriko NISHIYAMAMasahiro YOSHIYAMA
著者情報
キーワード: TGF-β1, BMP-2, bone formation
ジャーナル フリー

2018 年 16 巻 2 号 p. 74-79

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This study was designed to examine the effects of transforming growth factor-β1 (TGF-β1) and bone morphogenetic protein-2 (BMP-2) on bone formation using a bioabsorbable scaffold at palatal subperiosteal sites in rats.

Alginate gel containing TGF-β1 (0.0 or 0.1 μg /μL) and BMP-2 (0.0 or 0.1 μg /μL) were used for implantation, and experimental sites were divided into four groups according to the cytokines contained in the scaffold: TGF group (TGF-β1), BMP group (BMP-2), TGF+BMP group (TGF-β1 and BMP-2) and Control group.

Four weeks after implantation, thickness of new bone (TNB) was significantly higher in TGF group and BMP group than in Control group (P<0.05). There was no significant difference in TNB between TGF group and BMP group (P>0.05).

On the other hand, TNB was significantly higher in TGF+BMP group than in TGF group and BMP group (P<0.05).

These results suggest that TGF-β1 and BMP-2 contained in alginate gel have interactive effects on bone formation in the case of palatal subperiosteal sites.

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© 2018 by Japanese Association of Regenerative Dentistry
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