Journal of Oral Tissue Engineering
Online ISSN : 1880-0823
Print ISSN : 1348-9623
ISSN-L : 1348-9623
Original Articles
Effects of Direct Pulp Capping on Hard Tissue Formation by Using Alginate Gel Containing
Bone Morphogenetic Protein-2
Akihito YOKOYAMAKozo YAMAJINaoko OHARAKumiko MATSUZAKIYasushi SHIMADAMasahiro YOSHIYAMA
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ジャーナル フリー

2019 年 17 巻 2 号 p. 53-58

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The purpose of this study was to evaluate the effects of direct pulp capping on hard tissue formation by using alginate gel (AG) containing bone morphogenetic protein-2 (BMP2). Cavities with the exposed pulp areas were prepared on Wistar rats molars and were covered with AG containing BMP-2. Experimental sites were divided into two groups according to whether or not BMP-2 (0.1 µg/µL) was contained in AG. Then they were sealed with 4-META/MMA-TBB resin cement. In both groups, the covered materials were observed at one week after operation. At four weeks, they had disappeared, and the hard tissue formation was observed. Thickness of the hard tissue formation of AG containing BMP-2 group was significantly higher than that of AG without BMP-2 group (P < 0.05). These results suggest that AG containing BMP-2 has effects on hard tissue formation in the case of direct pulp capping.

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© 2019 by Japanese Association of Regenerative Dentistry
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