Accelerated Effect of MatriStem on Dentin Regeneration in                    Rats

Keiko ONJI; Toshiyuki KOIKE; Mohammad Ali Akbor POLAN; Md Riasat HASAN; Bayarchimeg ALTERHISHIG; Yaxin RAO; Youjin QIU; Yasuhiro MATSUDA; Kazuhisa BESSHO; Takashi SAITO

doi:10.11223/jarde.18.23

ORIGINAL ARTICLES

Accelerated Effect of MatriStem on Dentin Regeneration in Rats

Keiko ONJI, Toshiyuki KOIKE, Mohammad Ali Akbor POLAN, Md Riasat HASAN, Bayarchimeg ALTERHISHIG, Yaxin RAO, Youjin QIU, Yasuhiro MATSUDA, Kazuhisa BESSHO, Takashi SAITO

著者情報

Keiko ONJI
Division of Clinical Cariology and Endodontology, Department of Oral Rehabilitation, School of Dentistry, Health Sciences University of Hokkaido, Hokkaido, Japan
Takeru Dental Clinic, Tokyo, Japan
Toshiyuki KOIKE
Division of Clinical Cariology and Endodontology, Department of Oral Rehabilitation, School of Dentistry, Health Sciences University of Hokkaido, Hokkaido, Japan
K’s Dental Clinic, Osaka, Japan
Mohammad Ali Akbor POLAN
Department of Children Preventive and Community Dentistry, Dhaka Dental College, Dhaka, Bangladesh
Md Riasat HASAN
Division of Clinical Cariology and Endodontology, Department of Oral Rehabilitation, School of Dentistry, Health Sciences University of Hokkaido, Hokkaido, Japan
Bayarchimeg ALTERHISHIG
Division of Clinical Cariology and Endodontology, Department of Oral Rehabilitation, School of Dentistry, Health Sciences University of Hokkaido, Hokkaido, Japan
Yaxin RAO
Division of Clinical Cariology and Endodontology, Department of Oral Rehabilitation, School of Dentistry, Health Sciences University of Hokkaido, Hokkaido, Japan
Youjin QIU
Division of Clinical Cariology and Endodontology, Department of Oral Rehabilitation, School of Dentistry, Health Sciences University of Hokkaido, Hokkaido, Japan
Yasuhiro MATSUDA
Division of Clinical Cariology and Endodontology, Department of Oral Rehabilitation, School of Dentistry, Health Sciences University of Hokkaido, Hokkaido, Japan
Kazuhisa BESSHO
Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan
Takashi SAITO
Division of Clinical Cariology and Endodontology, Department of Oral Rehabilitation, School of Dentistry, Health Sciences University of Hokkaido, Hokkaido, Japan

キーワード: MatriStem, extracellular matrix, dentin regeneration, direct pulp capping, reparative dentin formation

ジャーナルフリー

2020 年 18 巻 1 号 p. 23-28

DOI https://doi.org/10.11223/jarde.18.23

詳細

抄録

The purpose of the present study was to investigate the effect of MatriStem derived from porcine bladder on reparative dentin formation and pulp inflammation in vivo compared with mineral trioxide aggregate and calcium hydroxide that have been used for vital pulp therapy. Exposed pulp tissue in the maxilla first molar of 8-week-old Wistar rats was covered with those materials. The rats were sacrificed 4 weeks after the operation. We performed histological examination of hematoxylin and eosin-stained sections of teeth that underwent direct pulp capping, followed by morphometric analysis of formed reparative dentin and evaluation of pulp inflammation. At 4 weeks, MatriStem formed highly compact, intensively reparative dentin with dentinal tubules. MatriStem induced less pulp inflammation than calcium hydroxide. This study suggests that MatriStem is a biocompatible, biodegradable, and bioactive material with growth factors such as bone morphogenetic proteins for dentin regeneration.

責任著者(Corresponding author)

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