Cell Proliferation in Cultured Human Deciduous Pulp Fibroblast-like Cells Treated with a Novel Dental Hypersensitivity Inhibitor at 43˚C

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During childhood and adolescence, dentin hypersensitivity with substantial loss of tooth structure such as erosive tooth wear and enamel hypoplasia becomes a clinical challenge. When using dental desensitizing agents for the treatment of dentin hypersensitivity, the biocompatibility of the material with dental pulp cells and its impact on wound healing are crucial. Dental desensitizing agents primarily composed of calcium carbonate exhibit biocompatibility with human deciduous pulp fibroblast-like cells. It is known that human deciduous pulp fibroblast-like cells can enhance cell proliferation ability under appropriate thermal stimulation. In an environment heated to 43°C for 15 minutes, heat shock proteins and after 24 hours, the proliferation of human deciduous pulp fibroblast-like cells is enhanced. In this study, the relationship between biocompatible dental desensitizing agents and thermal stimulation was investigated using human deciduous pulp fibroblast-like cells, revealing that cells cultured with the added material exhibited enhanced cell proliferation under conditions of thermal stimulation.