Effect of Bisphosphonate Immobilization of Apatite Coated Titanium Web on Trabecular Bone Response

Abstract

The trabecular bone response of bisphosphonate immobilized titanium web (TW) was investigated. Apatite thin film was coated onto TW using molecular precursor method. Sintered cylindrical TW was immersed into molecular precursor solution and then heated at 600^oC for 2 hr. The immersion and heating process was repeated three times. Apatite coated TW was immersed into the bisphosphonate solution (pamidronate disodium, 5x10^-3M) for 24 hr at 37^oC. Afterwards, TW, apatite coated TW and bisphosphonate immobilized TW were placed into the trabecular bone of femoral condyles of rabbits. Histological evaluation revealed that new bone formation was recognized inside the porous area of apatite coated TW and bisphosphonate immobilized TW after 12 weeks of implantation, and it appeared that bisphosphonate immobilized TW produced more new bone formation than apatite coated TW. It was suggested that bisphosphonate immobilized TW enhanced the osteogenesis inside area of TW.