Journal of Oral Tissue Engineering
Online ISSN : 1880-0823
Print ISSN : 1348-9623
ISSN-L : 1348-9623
ORIGINAL ARTICLE
Effects of Ultrasound on Bone Formation Induced by BMP-2
Kozo YAMAJIMaiko NISHIMURAYoshihiro NISHITANIShunji IZAWATomohiro HOSHIKAShintaro SHIODEMasahiro YOSHIYAMA
著者情報
キーワード: ultrasound, BMP, bone formation
ジャーナル フリー

2010 年 8 巻 1 号 p. 47-51

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抄録

Low-intensity pulsed ultrasound (LIPUS) is therapeutic instrument of improving bone healing, and Bone Morphogenetic Protein-2 (BMP-2) has been demonstrated to enhance bone formation. The present study was designed to evaluate the effects of LIPUS on bone formation induced by BMP-2 at palatal subperiosteal sites in Wister rats. Alginated gel (AG) contained BMP-2 (1.0µg/µL) was implanted into the palatal left site (BMP site), and AG alone was the right site (AG site). The rats were divided into two groups; LIPUS group, ultrasound (1MHz, 160mW, 5 min) was performed every three days, and non-LIPUS group. At 3 weeks after surgery, thickness of new bone of BMP site was significantly higher than that of AG site (P<0.05). Newly formed bone of BMP site was continuous with the original bone at non-LIPUS group, whereas it was almost integrated with the original bone at LIPUS group.
These results suggest that LIPUS has the ability to enhance the maturation of newly formed bone induced by BMP-2.

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© 2010 by Japanese Association of Regenerative Dentistry
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