2016 Volume 13 Pages 34-38
Background : Patients with schizophrenia have reduced physical activity levels due to the side effects of antipsychotic drugs, create negative conditions like extrapyramidal symptoms and over-sedation. However, few studies have examined the relationship between antipsychotic drug dosages and physical activity. Methods : A total of 16 Japanese outpatients with schizophrenia participated. Their physical activity levels were measured with a physical activity level meter. The patients were classified into groups according to standard equivalent conversions of chlorpromazine (CPZeq) : the high CPZeq group, >1000 mg ; and the low CPZeq group, ≦1000 mg. Physical activity between the groups was compared. Results : Total physical activity was significantly lower in the high CPZeq group (2.10±1.48 EX [1 EX＝1 metabolic equivalent for 1 h]) than in the low CPZeq group (4.47±2.01 EX). Physical activity by exercise was also significantly lower in the high CPZeq group (1.63±1.28 EX) than in the low CPZeq group (3.61±1.99 EX). Discussion : Our results suggest that patients with schizophrenia taking a high dose of an antipsychotic drug have decreased levels of physical activity, especially exercise. Further studies are needed to clarify the relationship between psychotic symptoms, factors of lifestyle and physical symptoms.
