Abstract
A rapid and simple analysis method for the chiral determination of methamphetamine (MA) and its metabolites, amphetamine (AP) and p-hydroxymethamphetamine (pOHMA), in urine by capillary electrophoresis (CE) has been developed. Urine sample was directly injected into the CE system after pretreatment of dilution and filtration. In the analyses of healthy people's urine samples spiked with MA, AP and pOHMA, the detection limits in urine were 0.5, 0.5 and 0.3 μg/ml, respectively. The recovery of each compound from urine was 95-105%. The proposed method was successfully applicable to the chiral analysis of urine samples from MA addicts.
