1991 Volume 3 Issue 2 Pages 63-70
Tumor cell kinetics in 13 cases of head and neck squamous cell carcinoma (SCC) treated by radiotherapy were analysed by immunohistochemical stain using anti-BrdU antibody, and correlated with therapeutic effect and histologic findings. The results were:(1) BrdU labeling index (B. L. I.) correlated with tumor regression speed and local control, which suggests correlation between the size of growth fraction and radiosensitivity.(2) Extent of reduction of BrdU-labeled cells after 10Gy irradiation correlated with tumor regression and local control.(3) B. L. I. correlated with differentiation of SCC. As the differentiation became poorer, B. L. I. increased, and the differentiation correlated with the distribution pattern of BLC. By analyzing tumor cell kinetics in addition to the usual methods, we can estimate radiosensitivity of the tumor more precisely and individualize andoptimize the therapy.
