Journal of Atherosclerosis and Thrombosis
Online ISSN : 1880-3873
Print ISSN : 1340-3478
ISSN-L : 1340-3478
Hepatic Lipase: a Comprehensive View of its Role on Plasma Lipid and Lipoprotein Metabolism
Junji KobayashiKazuya MiyashitaKatsuyuki NakajimaHiroshi Mabuchi
キーワード: HDL, EL, LPL, HL deficiency, Atherosclerosis
ジャーナル フリー

2015 年 22 巻 10 号 p. 1001-1011


Hepatic lipase (HL) is a key enzyme catalyzing the hydrolysis of triglycerides (TG) and phospholipids (PLs) in several lipoproteins. It is generally recognized that HL is involved in the remodeling of remnant, low-density lipoprotein (LDL), high-density lipoprotein (HDL) and the production of small, dense low-density lipoproteins (sd-LDLs).On the other hand, it is unclear whether HL accelerates or retards atherosclerosis. From the clinical point of view, HL deficiency may provide useful information on answering this question, but the rarity of this disease makes it impossible to conduct epidemiological study.In this review, we describe a comprehensive and updated view of the clinical significance of HL on lipid and lipoprotein metabolism.


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