Ophthalmic Artery Vasodilation after Intranasal Estradiol Use in Postmenopausal Women

Marco Matteo Ciccone; Ettore Cicinelli; Alessio Giovanni; Pietro Scicchitano; Michele Gesualdo; Annapaola Zito; Fara Fornarelli; Manuela Locorotondo; Maria Vittoria Cicinelli; Concetta Di Teo; Giuseppe Farinola; Domenico Scrutinio

doi:10.5551/jat.13904

This article has now been updated. Please use the final version.

Ophthalmic Artery Vasodilation after Intranasal Estradiol Use in Postmenopausal Women

Marco Matteo Ciccone, Ettore Cicinelli, Alessio Giovanni, Pietro Scicchitano, Michele Gesualdo, Annapaola Zito, Fara Fornarelli, Manuela Locorotondo, Maria Vittoria Cicinelli, Concetta Di Teo, Giuseppe Farinola, Domenico Scrutinio

Author information

Marco Matteo Ciccone
Cardiovascular Diseases Section, Department of Emergency and Organ Transplantation (DETO), University of Bari.
Ettore Cicinelli
Department of Ob/Gyn, University of Bari.
Alessio Giovanni
Department of Ophtalmology, University of Bari.
Pietro Scicchitano
Cardiovascular Diseases Section, Department of Emergency and Organ Transplantation (DETO), University of Bari.
Michele Gesualdo
Cardiovascular Diseases Section, Department of Emergency and Organ Transplantation (DETO), University of Bari.
Annapaola Zito
Cardiovascular Diseases Section, Department of Emergency and Organ Transplantation (DETO), University of Bari.
Fara Fornarelli
Cardiovascular Diseases Section, Department of Emergency and Organ Transplantation (DETO), University of Bari.
Manuela Locorotondo
Cardiovascular Diseases Section, Department of Emergency and Organ Transplantation (DETO), University of Bari.
Maria Vittoria Cicinelli
University San Raffaele.
Concetta Di Teo
Cardiovascular Diseases Section, Department of Emergency and Organ Transplantation (DETO), University of Bari.
Giuseppe Farinola
Division of Cardiology and Cardiac Rehabilitation. “S. Maugeri” Foundation, IRCCS, Institute of Cassano Murge.
Domenico Scrutinio
Division of Cardiology and Cardiac Rehabilitation. “S. Maugeri” Foundation, IRCCS, Institute of Cassano Murge.

Keywords: Estrogen therapy, Ophthalmic artery, Cerebral circulation, Menopause, Estradiol

JOURNAL OPEN ACCESS Advance online publication

Article ID: 13904

DOI https://doi.org/10.5551/jat.13904

The final version of this article is now available: Vol. 19 (2012), No. 12

Details

Abstract

Aim: The study aim was to evaluate the acute hemodynamic effects of intranasal 17-beta-estradiol on ophthalmic arterial circulation in postmenopausal women.
Methods: Twenty-one healthy women in natural menopause for at least 6 months (mean age: 53.2± 2.9 years) were investigated. Each patient received 300 µg intranasal 17-beta-estradiol. We evaluated the heart rate, systolic and diastolic blood pressure, ophthalmic artery velocity at systolic and diastolic peak and its flow curve integral (FCI) before and 30, 60 and 180 minutes after the administration of the drug.
Results: At all time points, the ophthalmic artery FCI showed statistically significant variations (p<0.001) of velocity (cm/sec) compared to T0 (speed recorded at baseline before drug administration). Moreover, systolic blood pressure, diastolic blood pressure and heart rate did not significantly differ each other after drug administration.
Conclusions: Administration of a single dose of intranasal 17-beta-estradiol to healthy postmenopausal women increases ophthalmic artery perfusion.

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