Abstract
We posturated that lysosomes involved in the accumulation of cholesterol ester in atheromatous aorta. To elucidale the mechanism further, we have developed cell culture system of foam cells from atheromatous aorta. The cells were prepared by the digestion of enzymes such as elastase, hyaluronidase and collagenase. Cross image, which may correspond to cholesterol ester inclusion bodies, was observed in living foam cells.
