Abstract
Experimental nephrotic syndrome was raisedin rat by intravenous injection of 6mg/kg BW of Daunomycin.
Lipoprotein analysis, lipid synthesis in liver and lipid metabolism in arterial wall were examined and the effect of KCD-232 (4-(4′-cholrobenzyloxy) benzyl nicotinate) which was compound to have lipid lowering effct was examined. Total cholesterol and triglyceride were remarkably increased in nephrotic syndrome and KCD-232 decreased those to almost the same extent as the control. Under nephrotic conditions, LDL-cholesterol, LDL-triglyceride and VLDL-triglyceride was increased.
Those lipoprotein disorders were improved by administration of KCD-232. Lipid synthesis from acetate or palmitate in liver was increased in nephrotic syndrome. Lipid synthesis, those are PL, TG and FFA from palmitate and lipid synthesis from acetate, was inhibited by administ ration of KDC-232.
Acid cholesterol esterase and lipase activity were increased in nephrotic syndrome and remained unchaged by administration of KCD-232.
