Abstract
Apolipoprotein C (apo C) percipitates great roles on lipid metabolism, especially on the catabolism of TG-rich lipoproteins. In vitro experiments, apo C II was recvealed to be an activator of lipoprotein lipase (LPL) and apo C III to be a inhibitor of LPL.
In present study, the percentage composition of apo C subgroup, apo C II, C III0 C III1 and C III2 in VLDL was obtained by scanning the gel after loading the apo-VLDL on isoelectric focusing gel.
The relationship between plasma lipids and percent composition of apo C subgroups was as follows, positive correlation existed in triglycerides (TG) vs. C III2, HDL-cholesterol (HDL-C) vs. C III0, TG vs. C II/C III0 ratio and HDL-C vs. C II/CII2 ratio and negative correlation in TG vs. C III0, HDL-C vs. C III2 and HDL-C C II/CIII0 ratio.
Pantethine (600mg/day) was prescribed to subjects, resulting the significant increase of plasma apo AI level, degrease of plasma TG and the increase of fractional removal rate of TG rich lipoprotein which was calculated from the decay curve of TG in Sf>400 fraction of plasma after intra-venous injection of Intralipid to the subjects (n=10). This drug also increased C II/C III0 ratio in VLDL significantly.
