We studied serum lipoproteins and apolipoproteins in the patients with or without coronary artery disease (CAD) in order to clarify the relationship between abnormal apolipoprotein metabolism and incidence of CAD.
The subjects in this study were 49 males and 51 females who were outpatients of our clinic or inpatients of coronary care unit.
Apolipoprotein (apo) A-I and A-II were determined by means of single radial immunodiffusion (SRID) method kit (Daiichi Pure Chemicals Co. Tokyo).
The subjects were divided into two groups according to the levels of T-CH, hypercholesterolemic group (T-CH≥250mg/dl) and normocholesterolemic group (T-CH<250mg/dl)
We studied the corrleationship between serum HDL and apo A-I or apo A-II, and the difference of serum apo A-I and A-II levels between the patients with and without CAD.
The results were as follows:
1) There was positive correlationship between HDL-CH and apo A-I or A-II, especially among males. The relationsip between HDL-CH and apo A was statistically stronger in CAD positive group than negative group.
2) The levels of apo A-I and apo A-II were significantly lower in CAD positive group, especially in males.
3) There was no significant difference in the ratios of apo A/HDL-CH between the patients with CAD and without.
4) The ratios of apo A/LDL-CH were singificantly low in CAD positive group and the higher this ratio the higher incidence of CAD.
