抄録
Seventy three patients with hyperlipidemia were examined. The clinical effects and side effects of Pentaerythritol tetranicotinate were examined in 73 patients with diabetes under the good chemical control, hypertension, ischemic heart disease. The hyperlipidemia was diagnosed in the patients either whose cholesterol level was over 220mg/dl or whose triglyceride level was over 180mg/dl. Significant reductions of cholesterol and triglyceride level were found in this study. On the other hand, a significant increase of HDL-cholesterol was also observed by the administration of this drug. There-fore, the atherogenic index significantly decreased. The remarkable changes of SGOT, SGPT, uric acid and fasting blood sugar were not observed through the period of treatment. In the diabetic patients, the glucose tolerance before and after the treatment was not changed. As for the side effects, in 7 patients flushing, in 3 patients los of appetite, and in 2 cases the increase of uric acid were observed, respectively. But these side effect were not serious and the administration could continue.
