家族性高コレステロール血症に対するプロブコールの脂質低下作用について ―HDL<sub>2</sub>, HDL<sub>3</sub>の変動について―

宮元 進; 竹越 忠美; 追分 久憲; 浅香 敏; 井村 優; 竹内 伸夫; 篠崎 公秀; 西野 知一; 馬渕 宏

doi:10.5551/jat1973.11.3_683

Effect of Probucol on Serum Lipoprotein Lipids in Patients with Familial Hypercholesterolemia

-Changes in HDL Subfraction-

Susumu MIYAMOTO, Tadayoshi TAKEGOSHI, Hisanori OIWAKE, Satoshi ASAKA, Suguru IMURA, Nobuo TAKEUCHI, Kimihide SHINOZAKI, Tomokatsu NISHINO, Hiroshi MABUCHI

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Keywords: Probucol, Familial Hypercholesterolemia, HDL Subfraction

JOURNAL OPEN ACCESS

1983 Volume 11 Issue 3 Pages 683-686

DOI https://doi.org/10.5551/jat1973.11.3_683

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Abstract

Probucol (1g/day) was administered for 6 months to 10 hypercholesterolemic patients. Total serum cholesterol fell by 13%, LDL cholesterol by 12%, HDL₂ cholesterol by 20% and HDL₃ cholesterol by 14%. The serum, LDL and HDL free cholesterol levels were significantly reduced during probucol treatment. The ratio of total cholesterol to free cholesterol in serum, VLDL and LDL was significantly increased. Thus, probucol appeared to reduce especially free cholesterol in VLDL and LDL fractions.

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