Abstract
Serum lipoproteins and apolipoproteins in VLDL and HDL from SHR aged 40 weeks were analyzed by ultracentrifugation and isoelectrofocusing, and compared with those from Wistar Kyoto rat (WKR) with the same ages. These results are summarized as follows;
(1) Concentrations of every serum lipids from SHR were higher than those from WKR except HDLC. Serum TG of SHR was 2.5 times higher than that of WKR.
(2) Concentrations of VLDL and LDL from SHR were elevated when compared with those from WKR, especially the elevation of VLDL was remarkably. As no significant difference was found between HDL from both groups, the percentage of VLDL to total lipoproteins increased and that of HDL decreased in SHR.
(3) The increased percentage of TG and the decreased PL were observed in VLDL fraction from SHR. In LDL and HDL fractions of this rat, the percentages of CH and PL increased, and those of apoproteins and TG decreased.
(4) Although apo CII/CIII ratio and apo CIII composition in VLDL were not significantly different between both groups, the ratio of apo E protein decreased in VLDL of SHR. There were the reduction of apo A protein ratio and the increases of apo E and C protein ratios in HDL fraction. The apo E/C ratio decreased both in VLDL and HDL, which might influence the interaction between serum lipoproteins and liver, whether it was induced primarily or secondarily.
