抄録
3.5% polyacrylamide gel electrophoresis in 0.1% sodium dodecyl sulfate was employed to separate the apoprotein (apo) B subclasses, apo B-100 and apo B-48, of very low density lipoproteins (VLDL), intermediate density lipoproteins (IDL) and low density lipoproteins (LDL) in patients on maintenance hemodialysis and in normal controls. The results were as follows.
1) In uremic patients, there was significantly an increase in the percent apo B-48 of VLDL and a reverse change of the apo B-100/B-48 ratio.
2) Similar results were obtained in relation to the distributions of apo B subclasses in IDL. In addition, some patients had a apo B-74 which could be a degradation product of apo B-100.
3) Small amounts of apo B-48 were detected in the LDL of some patients, while no apo B-48 was observed in the LDL of normal controls.
4) There was no significant relationship between serum triglyceride levels and the existence of apo B-48 in each apo B-containing lipoprotein of patients on maintenance hemodialysis.
