The present study aimed to clarify the longterm effect of Soysterol on arteriosclerosis as measured by aortic pulse wave velosity (PWV). Control group consisted of 20 males and 15 females, 35 in total in ages from 46 to 82 years (average age 67.5 years), while Soysterol group consisted of 19 males and 15 females, 34 in total in ages from 33 to 79 years (average age 63.4 years). Soysterol was dosed at 1200mg per day in Soysterol group and all subjects were measured for PWV every 3 months. The period of observation were 31 to 118 months (average 82.4 months) in control group and 11 to 54 months (average 40.8 months) in Soysterol group.
PWV increased from 8.14m/sec to 11.7m/sec after 90 months for control group and from 9.14m/sec to 9.46m/sec after 50 months in Soysterol group, with regression coefficient of 0.0367 for former against lower regression coefficient of 0.0174 for the later. Significant differences (p<0.05 to 0.01) were observed in PWV between both group on and after 20 months of observation.
