抄録
The plasma lipids and lipoproteins of rats developing obesity after neonatal administration of monosodium glutamate (MSG) were compared with those obtained from controls. The MSG-treated rats were stunted and had enlarged adipose tissues. These rats revealed a marked increase of plasma triglyceride and a slight but significant increase of phospholipids in both male and female. There was no significant difference in plasma cholesterol between the MSG-treated rats and the controls. The lipids and protein concentrations of very low density lipoprotein (VLDL: d<1.006g/ml) were significantly more increased in the MSG-treated rats than in the controls. But there were no compositional changes in these increased VLDL, which indicated that the number of VLDL particle was increased. The degrees of the increment of plasma triglyceride and lipids components of VLDL were significantly more pronounced in males than in females. There were no significant differences in plasma concentrations of apolipoprotein E and A-I between the MSG-treated rats and the controls.
In spite of hypophagia, both male and female MSG-treated rats had a higher plasma glucose level than sex-matched controls. The plasma insulin level was higher in male MSG-treated rats (49.3±6.6μU/ml [SE]) than in female MSG-treated rats (14.8±3.2μU/ml) or in male control rats (34.6±6.6μU/ml). These results suggested that hyperinsulinemia plays an important role in the increase of VLDL observed in the MSG-treated rats.
