抄録
We have Postulated that lysosomal acid cholesterol esterase involved in the accumulation of cholesterol ester in atheromatous aorta. We found that cholesterol ester in cultured smooth muscle cells increased 12.68 times of control in the presence of LDL (220μg cholesterol equivalent) and esterastin (500μM) as an inhibitor of acid cholesterol esterase. These experiments may help to elucidate the mechanism of accumulation of cholesterol ester in smooth muscle cells in vitro.
