Serum levels of lipids (Total cholesterol: TC, Triglyceride: TG and HDL cholesterol: HDL-C) and apoproteins (Apo A-I, A-II, B, C-II, C-III and E) were measured in survivors of cerebral infarction (C. I.) and in healthy controls. Apoproteins were measured by a single radial immunodiffusion method (Apoplate, Daiichi Chemicals: Tokyo). TC and TG levels were higher, and the HDL-C level was considerably lower in C. I. survivors than in healthy controls. Apo A-I and A-II levels tended to be lower, Apo B level was remarkably higher, and the levels of Apo C-II, C-III and E were higher in C. I. survivors than in healthy controls.
HDL-C/Apo A-I and TC-HDL-C/Apo B ratio were lower in C. I, survivors, and it was suggested that these ratios are useful as parameters representing the compositional abnormalities of HDL or LDL particles.
Among the C. I. survivors, there were some cases whose Apo E/TG ratios were higher than those of healthy contorols, suggesting the accumlation of VLDL remnants.
