実験的冠動脈硬化と攣縮発生に関する研究(第II報)

抄録

It was attempted during this study that coronary spasm in the same segments of the coronary arteries of swine was caused repeatedly by methacholine administration to elucidate whether or not vascular permeability might be accelerated in those segments. Immunohistochemistry with a use of anti-swine fibrinogen antibody revealed granular deposition of the reaction products in subendothelial areas of intima and infra-elastic space in the segments of the arteries, where arterial spasm was proven to appear by cineangiography and ECG. Electron microscopical study revealed more appearance of ferritin particles in subendothelial areas of the intima than that of control swine coronary arteries.
The results are as follows;
1. Pre-existence of some organic diseases such as arteriosclerosis in the coronary arteries may lead to higher incidence of coronary spasm. However, it may not always occur in the sclerotic segments but does so in the more distal nonsclerotic segments of the coronary arteries.
2. Repeated arterial spasm may lead to accelerate vascular permeability.
3. Vasospasm may be one of pathogenetic factors of coronary sclerosis.