To assess the significance of various apolipoproteins on the development of coronary atherosclerosis, coronary arterial stenotic score determined angiographically were compared with the levels of apolipoprotein A-I, A-II, B, C-II, C-III, E in the plasma and in each lipoprotein.
In the group with high stenotic score, total cholesterol, apolipoprotein B in the plasma, apo B in LDL, apo C-II in VLDL and apo A-I in HDL3 were significantly increased in spite of having no significant differences in LDL and HDL-cholesterol. Apolipoprotein E showed no significant difference between two groups. The distribution of apo A-I in HDL2 and HDL3 was different in two groups with high and low stenotic score. The possibilities should be further investigated whether there was a weak association of apo A-I with lipids in high stenotic group.
Apo B in the plasma, apo B in LDL apo A-I in HDL3 were significant indicators of advanced coronary atherosclerosis.
