動脈硬化症における血小板機能とプロスタノイド

抄録

Platelet aggregation, circulating platelet aggregates (ratio), plasma β-thromboglobulin, plasma prostanoid (6-keto-PG F_1α, TX B₂), plasma apoprotein and plasma sialic acid were measured in patients with atherosclerosis and non-atherosclerotic disease, e. g, chronic obstructive pulmonary disease, and in healthy subjects to clarify the significance of platelet function and plasma prostanoid in atherosclerosis.
The group A serving as the healthy subjects consisted of 33 men of the average age 41.5 years, the group B consisted of 214 men of the average age 67.6 years and with ischemic heart disease and cerebral infarction in chronic state, and the group C consisted of 106 men of the average age 62.3 years and with non-atherosclerotic disease, mainly chronic obstructive pulmonary disease.
In the group B ADP-, collagen-, adrenaline- and arachidonic acid-induced platelet aggregation and circulating platelet aggregates were significantly enhanced compared to both the group A and the group C. As for plasma β-thromboglobulin, there was no significant difference between the three groups. Plasma apoprotein A-I was significantly increased in the group C compared to both the group A and the group B. Plasma sialic acid was significantly increased in the group B compared to both the group A and the group C. Significant positive correlation of TX B₂ to β-thromboglobulin and significant negative correlation of 6-keto-PG F_1α to apoprotein B were found in group B.
These results suggest that the enhancement of platelet function may play a role in atherogenesis with relation to the prostanoid production, plasma apoprotein and sialic acid.