Studies on The Correlation between Apo-lipoproteins and Fatty Acids in Hachijo Island

Abstract

Apo-lipoproteins constitute an important factor in arteriosclerosis. Dyerberg et al. demonstrated that Eicosapentaenoic acid (EPA) acts as an antiarteriosclerotic substance. However, the relationship between the amount of apo-lipoproteins and the content of fatty acids in serum remains unclear. Considering these circumstances, we attempted the analysis of serum fatty acids and the estimation of some apo-lipoproteins (Apo A-I, Apo A-II, Apo C-II and Apo E).
Blood samples were drawn from 45 subjects of healthy male and female. Fatty acids were analyzed by Gas chromatography and amounts of apolipoproteins were estimated by the method of SRID. No correlation was observed between fatty acids and either Apo A-I or Apo A-II. But there was a positive tendency between A-I/A-II ratio and the contents of EPA and DHA. A positive correlation was observed between Apo C-II and saturated fatty acids as well as monounsaturated fatty acids, but no correlation between Apo C-II and polyunsaturated fatty acids except for DHA. A positive correlation was also observed between Apo E and saturated fatty acids, but no correlation between Apo E and unsaturated fatty acids except for DHA.