Plasma lipids, lipoprotein lipids and apolipoproteins were measured in 17 normolipidemic male patients with vibration disorder. All subjects had no other disease. Alcohol drinkers (n=9) were susteined abstinence during hospitalization for 6 weeks. There were no significant levels of these lipids and apolipoproteins between drinkers and non-drinkers (n=8) at the time of discharge.
The initial plasma triglycerides, apolipoprotein (apo) C-II, apo C-III, apo C-II/apo E and apo C-III/apo E levels were higher in drinkers than these in non-drinkers. The levels of apo C-II an apo C-III decreased significantly by abstinence. There were significant correlations between plasma triglycerides and apo C-II in non-drinkers at the time of admission and of discharge. This correlation did not exist in drinkers at the time of admission.
The values of LDL-cholesterol and apo B were not significant between in drinkers and in nondrinkers. These values were not changed during hospitalization. There were significant correlations between LDL-cholesterol and apo B in nondrinkers. This correlation did not exist in drinkers at the time of admission and there was significant correlation between apo B and plasma triglycerides in drinkers.
Initial HDL-phospholipids was higher in drinkers than in non-drinkers. Although, the values of HDL-cholesterol, apo A-I and apo A-II in drinkers were not significant in comparison with those in non-drinkers. These values decreased significantly in drinkers by abstinence.
These findings suggest that apo C-II and apo C-III are changed on these values in plasma and their distributions on lipoproteins by chronic alcohol intake. Apo B is changed its distribution on lipoproteins by alcohol consumption. Finally, HDL-cholesterol, apo A-I and apo A-II increase by alcohol drinking.
