Abstract
Serum lipoprotein and apoprotein were determined in 154 non-insulin dependent diabetes aged from 17 to 78 years. The 154 patients were divided into 3 groups, by their age: those below 39, those 40 to 59 and those above 60. Each of the 3 groups was divided again into 2 subgroups by hyperlipemia (TC≥250mg/dl and/or TG≥150mg/dl) and normolipemia (TC<250mg/dl and TG<150mg/dl). Control Subjects for apoprotein were 7 healthy volunteers aged below 39, and also normal controls from the references No. 6. The results obtained were as follows:
1) In the normolipemia with and without arteriosclerosis the serum levels of VLDL, LDL, HDL-cholesterol (HDL-C) and apoprotein (A, C and E) were in the normal range. But only apo B was higher than the normal levels in all diabetic groups.
2) The levels of VLDL and LDL were increased and HDL-C was decreased significantly in the hyperlipemia when compared with in the normolipemia. Apo B, C and E in the hyperlipemia showed significantly higher than in the normolipemia, while apo A-I and apo A-II didn't differ statistically between in the normolipemia and hyperlipemia.
3) Atherogenic Index (AI) was increased more significantly in the patient with hyperlipemia than with normolipemia.
On the other hand the apo B/apo A-I ratio were higher in both diabetic groups with hyperlipemia and with normolipemia than in controls. Apo B/apo A-II ratio also showed the same results.
We conclude that apo B and apo B/apo A-I ratio or apo B/apo A-II ratio were increased in all diabetic patients, especially even in the normolipemic diabetics aged under 39. High levels of apo B might have atherogenic effects even on the young normolipemic diabetic patients.
