Abstract
In order to clarify the role of apoproteins on the pathogenesis of diabetic micro- and/or macroangiopathy, serum total cholesterol (t-chol), triglycerides (TG), HDL-cholesterol, apoprotein A-I (apo A-I), A-II (apo A-II) and B (apo B) were measured in 10 normal subjects and 22 patients with type II diabetes mellitus (DM). DM were divided into two groups as follows: 1) DM without proliferative retinopathy (DM-ret (-)), 2) DM with proliferative retinopathy (DM-ret (+)).
Both serum t-chol and TG of DM were significantly higher than those of normal subjects, but there was no significant differences in both t-chol and TG between DM-ret (-) and DM-ret (+).Serum HDL-cholesterol levels of both DM-ret (-) and DM-ret (+) were within normal range. Serum apo A-I of normal subjects, DM-ret (-) and DM-ret (+) was 128±7mg/dl, 179±48mg/dl and 202±60mg/dl, respectively, and serum apo A-I of DM was remarkably higher than that of normal subjects (p<0.05). Serum apo A-II of DM was higher than that of normal subjects (40±1mg/dl), but there was no significant differences between DM-ret (-) (55±21mg/dl) and DM-ret (+) (50±16mg/dl). Serum apo B of normal subjects, DM-ret (-) and DM-ret (+) was 85±15mg/dl, 166±59mg/dl and 155±99mg/dl, respectively. Serum apo B of DM was significantly higher than that of normal subjects (p<0.001), but there was no significant differences between DM-ret (-) and DM-ret (+).
These data suggest that elevated apo A-I, A-II and B due to the disturbance of apoprotein metabolism in type II diabetes mellitus may play an important role on the progress of diabetic atherosclerosis, but may be little importance for microangiopathy such as proliferative retinopathy.
