Abstract
Eicosapentaenoic acid (EPA) is known to have anti-atherogenic and anti-thrombotic effects. Effects of plasma polyunsaturated fatty acids (EPA, DHA, AA) on plasma apolipoproteins (A-I, A-II, B, A-I/A-II ratio, A-I/B ratio) were examined in healthy 98 people at Hachijo Island.
The results were as follows:
1) EPA/AA ratio (0.6±0.3) of people in Hachijo Island was higher than that of city people (0.45±0.20).
2) The levels of EPA and DHA showed negative correlation with level of HDL.
3) The level of EPA showed positive correlation with levels A-I and B, DHA showed positive correlation with levels of A-II and B, AA showed positive correlation with A-I and B and EPA/AA ratio showed no significant correlation with apolipoproteins.
4) The levels of EPA showed negative correlation with A-I/B ratio, DHA showed negative correlation with A-II/B ratio, AA showed negative correlation with A-I/A-II ratio and EPA/AA ratio showed negative correlation with A-I/B ratio.
5) A-I/A-II ratio and A-I/B ratio were significantly lower in high TC group than middle and low TC group.
