Abstract
We studied the relationship between plasma lipids and apo E4/2 phenotype. Apo E phenotypes were determined by the rapid flat gel isoelectric focusing method that we reported previously. The frequency of apo E4/2 phenotype was 0.92 (4/436). Three of the subjects with apo E4/2 phenotype had type IV hyperlipoproteinemia. They showed normal laboratory data except for the lipids. The other subject had diabetes mellitus of 11 years' duration and had type III hyper-lipoproteinemia. The families of three subjects had the rare phenotypes of apo E3/2, E2/2 and E4/3, and most of them had type ha, IIb or IV hyperlipoproteinemia. In conclusion, apo E4/2 phenotype may be associated with type IV or III hyperlipoproteinemia, and apo E2 and E4 may be associated with the occurrence of lipid abnormalities.
